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KMID : 1134820120410081072
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 8 p.1072 ~ p.1078
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Antioxidant and Anti-inflammatory Effect of Extracts from Flammulina velutipes (Curtis) Singer
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Kang Hyun-Woo
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Abstract
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The potential antioxidant and anti-inflammatory effect of water and ethanol extracts from Flammulina velutipes (Curtis) Singer (FVS) on hydrogen peroxide (H2O2) and LPS-induced oxidative damage in PC-12 and RAW264.7 cells were investigated. The DPPH radical scavenging activities of the water extract from FVS was the highest, and the 50% inhibitory concentration value was 0.388 mg/mL. Also, the antioxidant activities of water and ethanol extracts were determined by ferric reducing antioxidant power, 2,2'-azino-bis-(3-ethybenzothiazoline-6-sulphonic acid) radical scavenging activity. In addition, water extract from FVS showed a strongly inhibitory effect on lipid peroxidation by measuring ferric thiocyanate values. The water extract decreased cell apoptosis in PC-12 cells against H2O2-induced oxidative damage. In addition, FVS extracts exhibited the strongest nitric oxide (NO) inhibition activity. It was also found that FVS extract inhibited LPS-induced iNOS and COX-2 expression in RAW264.7 cells. The findings of the present study suggest that extracts of FVS exhibit anti-oxidative and anti-inflammatory activity against oxidative stress and/or stimulated cells.
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KEYWORD
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antioxidant, anti-inflammation, Flammulina velutipes (Curtis) Singer, hydrogen peroxide
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